Update: 20 of the 51 fatalities confirmed so far in #Moore tornado are children, says State medical examiner's office
Update: 51 people confirmed dead after a monstrous tornado ripped through Oklahoma City suburbs, flattening entire neighborhoods with winds over 200 mph.
|Loop of the Moore Tornado Radar, OK EF5|
Seven of the dead were children from Plaza Towers Elementary School in Moore, which lay directly in the path of the monster storm's wall of wind.
Seventy-five students and staff members had been huddled the school when the storm hit, CNN affiliate KFOR reported.
As nightfall approached, determined searchers in hard hats dug in the debris for students possibly trapped, but authorities described the work as a recovery, not rescue, effort.
Photos: Tornadoes wreak havoc in Midwest
A temporary flight restriction was put in place over the school so that aircraft would stay away and emergency officials on the ground might hear any cries for help, said Lynn Lunsford with the Federal Aviation Administration.
After the ear-shattering howl of the killer storm subsided, survivors along the miles of destruction emerged from shelters to see an apocalyptic vision -- the remnants of cars twisted and piled on each other to make what had been a parking lot look like a junk yard. Bright orange flames flew from a structure that was blazing even as rain continued to fall.
"Our worst fears are becoming realized this afternoon," Bill Bunting, with the National Oceanic and Atmospheric Administration's Storm Prediction Center, told CNN.
"We certainly hope everyone heeded the warnings, but it's a populated area and we just fear that not everyone may have gotten the word," he said.
Bodies of those killed in the storm were being sent to Oklahoma's office of the chief medical examiner, said the office's Amy Elliott. Authorities had no immediate estimate on the number of injured.
The preliminary rating of damage created by the tornado is at least EF4 (winds 166 to 200 mph) -- the second-most severe classification on a scale of zero to five -- the National Weather Service said.
The tornado was estimated to be at least two miles wide at one point as it moved through Moore, KFOR reported.
Lando Hite, shirtless and spattered in mud, told the affilaite about the storm hitting the Orr Family Farm in Moore, which had about 80 horses.
"It was just like the movie 'Twister,'" he said, standing amid the debris. "There were horses and stuff flying around everywhere."
The tornado damaged several barns and he was worried many of the animals were killed.
Hite said he did not hear any warnings or sirens.
"It was real windy and everything stopped. Being from Oklahoma, I knew that was not right."
Twenty patients, including 12 adults and eight children, were in trauma rooms at Oklahoma University (OU) Medical Center and at the Children's Hospital at OU Medical Center, said spokesman Scott Coppenbarger.
Injuries ranged from minor to critical.
Moore Medical Center in Oklahoma was evacuated after it sustained damage, a hospital spokeswoman said.
All patients were being evacuated to Norman Regional Hospital and Healthplex Hospital, and residents injured in the storm were being told to go to those centers as well.
Norman Regional Hospital and the Healthplex were treating an unspecified number of people with "signs of trauma, lacerations and broken bones," spokeswoman Melissa Herron said.
Interstate 35 in Moore was closed as a result of debris from the tornado, Oklahoma Department of Transportation spokesman Cole Hackett said. Crews were heading to the north-south highway to start the cleanup process.
"People are trapped. You are going to see the devastation for days to come," said Betsy Randolph, spokeswoman for Oklahoma Highway Patrol. She did not say how many people were trapped.
More than 38,000 electricity customers in Oklahoma are without power, according to local power providers.
Even as authorities and rescue workers struggle to get handle on the damage, NOAA's Bunting warned the worst may be yet to come.
"These storms are going to continue producing additional tornadoes. They'll also produce some very, very large hail, perhaps larger than the size of baseballs. We're also concerned that there may be an enhanced and widespread damaging wind threat with storms as they merge together," he said.
"As bad as today is, this is not over yet."
Oklahoma resident: 'It's just all gone'
The severe weather came after tornadoes and powerful storms ripped through Oklahoma and the Midwest earlier Monday and on Sunday.
Forecasters had said that the destructive weather, which killed at least two people, was perhaps just a preview.
Even before Monday afternoon's devastation, residents in areas hard hit by weekend storms were combing through rubble where their homes once stood.
"My mind is, like, blown, completely blown," said Jessie Addington, 21, who found that few pieces of her childhood home in Shawnee, Oklahoma, were still standing Monday.
Addington, who now lives in a nearby town, said her mother huddled in the mobile home's bathroom when the weekend storm hit. But the tornado still tossed her around like a rag doll, leaving her bruised.
When Addington arrived, she was shocked to find the neighborhood where she had lived for 17 years reduced to ruins.
"I'm feeling cheated, to be honest," she said, "like, it's just all gone."
An estimated 300 homes were damaged or destroyed across Oklahoma in weekend weather, Red Cross spokesman Ken Garcia said.
Two men, both in their 70s, were confirmed dead as a result of an earlier tornado that hit Shawnee, said Elliott, the spokeswoman for the state medical examiner's office.
As many as 28 tornadoes were reported in Oklahoma, Kansas, Illinois and Iowa, according to the National Weather Service, with Oklahoma and Kansas the hardest hit. Some of those reports might have been of the same tornado.
A combination of factors -- including strong winds and warm, moist air banging against dry air -- means severe weather could continue sweeping across a wide swath of the United States for days, Petersons said.
"Keep in mind we have all the ingredients out there that we need," she said.
Tornado watches were in effect for portions of southeastern Kansas, western and central Missouri, northwest Arkansas, central and eastern Oklahoma and northwestern Texas until 10 p.m. (11 p.m. ET).