Lentonitrat: Fact or Fiction? Mail-order explosive heart drug

TRUE

CAL FIRE NEWS is researching the use of a alleged "heart Drug known as "Lentonitrat" which supposedly is also the same high explosive PETN recently used in the failed airline bomb plot and supposedly can be purchased in Kilo quantities over the internet! So far we have not found any evidence to the contrary.

Actually this seems to be "Old News" Same stuff Richard Reid the shoe bomber used and the drug properties were discussed online and print during that time.

Also called: Nitropentaerythritol. Available as capsules and tablets. "May be swallowed whole or chewed".

Google comes up with a page at http://www.medic8.com/medicines/Pentaerithrityl-tetranitrate.html part of which contains the following information ""PETN is also used as a vasodilator. The medicine for heart diseases, "Lentonitrat", is pure PETN.""

Another article is quoted as saying: ""PETN is even more easily available as it is used as a heart medicine. The vasodilator, Lentonitrat, is almost pure PETN. Less than one kg is required to bring down an airliner. All one needs to do is to buy a kilo of Lentonitrat from a medical supplier and install detonators and trigger circuits."" - Article link

Pharmalogical and Administration notes from Global Security: In 1995 Haustein KO, Winkler U, Loffler A, Huller G. of the Abteilung Klinische Pharmakologie, Medizinische Hochschule Erfurt, Germany reported on a study of PETN's cardiovascular effects. The effects of 80 mg pentaerithrityl-tetranitrate (PETN) as suspension or formulated as tablets were compared to placebo in a single blind, randomized, crossover study in 18 healthy subjects (study A), and the bioequivalence of two tablet formulations (marketed Dilcoran 80 vs a new formulation) was studied in 24 healthy subjects after administration of single oral doses of 80 mg PETN according to a placebo controlled, randomized, double blind, two-way crossover study design (study B). The perfusion of the right middle finger was measured by rheography (altitude A of the changes of resistance and of the incisure D) before and 24 h post-dose, and blood pressure and heart rate were measured in supine position at the same time. The values of area under curve (AUC) of the ratio A/D were calculated by the trapezoidal rule. In study A the mean A/D-values were reduced from about 2.0 to about 1.3 after intake of PETN (solution or tablet) with a minimum 60 to 90 min postdose (solution) and 2 h postdose (tablet). A significant reduction in this ratio was seen up to 8 (solution) or 12 h (tablet) post dose. Changes in blood pressure were not observed while the heart rate decreased in the subjects of all three groups 1 to 2 h postdose followed by an increase by 6 to 10 beats per min. After subtraction of the AUC values of placebo from the PETN-derived AUC values, mean values of 6.61 (SD 1.52, solution) and 7.25 (SD 1.48, A/D*h, tablet) were calculated (p > 0.1, study A).- Article Link

PETN

PETN (Pentaerythritol Tetranitrate, also known as Penthrite) is one of the strongest known high explosives, with a relative effectiveness factor (R.E. factor) of 1.66. It is more sensitive to shock or friction than TNT or tetryl, and it is never used alone as a booster. It is primarily used in booster and bursting charges of small caliber ammunition, in upper charges of detonators in some land mines and shells, and as the explosive core of detonation cord.

PETN is one of the explosive ingredients used in Semtex plastic explosive. During World War II the M9A1 2.36" Rocket Launcher (Bazooka) shaped charge, with 8 oz of pentolite (a mixture of PETN and TNT), could penetrate up to 5 inches of armor.

Demolition charge, M118, commonly called Flex-X or sheet explosive, consists of 4 half-pound sheets of flexible explosive packed in a plastic envelope. Each sheet is approximately 3 inches wide, 12 inches long, and � inch thick. Note: The exact explosive contained in an M118 charge varies with the manufacturer. At present, some manufacturers use PETN as the basic explosive. Others use RDX. Charges manufactured in the future may include other explosives.

PETN is also used as a vasodilator. The medicine for heart diseases, "Lentonitrat", is pure PETN.

PETN was also used by Richard Reid for the plot to destroy American Airlines Flight 63 by trying to ignite explosives hidden in his shoes.

Properties

The velocity of detonation of PETN at a density of 1.7 is 8,400 meters per second.

PETN's formula is C(CH2ONO2)4. Its theoretical maximum crystal density is 1.773 g/cm3. It melts toward 141 �C.

As a pollutant in the environment

PETN does not occur naturally, so the production and use of this kind of compound can lead to contamination of the environment. PETN is subject to biodegradation in untreated or unpreserved urine and feces. There also have been some reports of its degradation by bacteria, whose PETN reductase denitrates PETN into trinitrates and then dinitrates (French et al., 1996). The last compound shown in the pathway, pentaerythritol dinitrate, is degraded further to unknown products.

Production

PETNs' preparation involves the nitration of pentaerythritol with a mixture of concentrated nitric and sulfuric acid. The preferred method of nitration is the ICI method, which utilizes concentrated nitric acid (98%+) alone, as mixed acid can create unstable sulfonated by-products. C(CH2OH)4 + 4HNO3 → C(CH2ONO2)4 + 4H2O

More PETN Information:

PETN [Pentaerythritol tetranitrate]

Pentaerythritol tetranitrate, C5H8N4012 (PETN), has a specific gravity of solids of 1.76 and a confined detonation velocity of over 25,000 fps. PETN is used as a priming composition in detonators, a base charge in blasting caps, and a core load for detonating fuse. PETN is very much used in Detonating Cord of which it is the explosive core (Primacord), where it develops a velocity rate of 21,000 feet per second. Detonating cord is insensitive to friction and ordinary shock, but may be exploded by rifle fire. It also detonates sympathetically with the detonation of an adjacent high explosive.

PETN is one of the strongest known high explosives with a relative effectiveness factor (R.E. factor) of 1.66. It is more sensitive to shock or friction than TNT or tetryl, and it is never used alone as a booster. It is primarily used in booster and bursting charges of small caliber ammunition, in upper charges of detonators in some land mines and shells, and as the explosive core of primacord.

During World War II the M9A1 2.36" Rocket Launcher (Bazooka) charge, with 8 oz of pentolite, could penetrate up to 5 inches of armor.

Demolition charge, M118, commonly called Flex-X or sheet explosive, consists of 4 half-pound sheets of flexible explosive packed in a plastic envelope. Each sheet is approximately 3 inches wide, 12 inches long, and 1/4 inch thick. Note: The exact explosive contained in an M118 charge varies with the manufacturer. At present, some manufacturers use PETN as the basic explosive. Others use RDX. Charges manufactured in the future may include other explosives.

PETN does not occur naturally, so the production and use of this kind of compound can lead to contamination of the environment. PETN is subject to biodegradation in untreated or unpreserved urine and feces. There also have been some reports of its degradation by bacteria, whose PETN reductase sequentially denitrates PETN into tri- and dinitrates (French et al., 1996). The last compound shown in the pathway, pentaerythritol dinitrate, is degraded further to unknown products.